This Technical Report provides guidance for the physico-chemical characterization of manufactured nano- objects and their aggregates and agglomerates (NOAA) greater than 100 nm presented for toxicological testing in order to aid in assessing and interpreting the toxicological impact of manufactured nano-objects and to allow the material under test to be differentiated from seemingly similar materials. For each of the selected properties, a description, clarification, relevance, measurand and example measurement methods are provided.<\/p>\n
This Technical Report will be of value to parties (e.g. toxicologists, ecotoxicologists, regulators, health and safety professionals) interested in assessing and interpreting the potential toxicological effect of manufactured NOAAs.<\/p>\n
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|---|---|---|---|---|---|---|---|
| 3<\/td>\n | CVP_Secretariat_Loca <\/td>\n<\/tr>\n | ||||||
| 6<\/td>\n | Foreword <\/td>\n<\/tr>\n | ||||||
| 7<\/td>\n | Introduction <\/td>\n<\/tr>\n | ||||||
| 9<\/td>\n | 1\tScope 2\tTerms and definitions <\/td>\n<\/tr>\n | ||||||
| 14<\/td>\n | 3\tSymbols and abbreviated terms 4\tImportance of physico-chemical properties to toxicological assessment 4.1\tThe purpose of toxicological experimentation <\/td>\n<\/tr>\n | ||||||
| 15<\/td>\n | 4.2\tGeneral methods of toxicological testing and risk assessment <\/td>\n<\/tr>\n | ||||||
| 16<\/td>\n | 4.3\tPhysico-chemical properties of nano-objects <\/td>\n<\/tr>\n | ||||||
| 17<\/td>\n | 4.4\tPurity and impurity of tested nano-objects 4.5\tWhen to undertake physico-chemical characterization <\/td>\n<\/tr>\n | ||||||
| 18<\/td>\n | 4.6\tPotential problems with materials assessment <\/td>\n<\/tr>\n | ||||||
| 19<\/td>\n | 5\tParameters for the physico-chemical characterization of manufactured nano-objects prior to toxicological assessment 5.1\tGeneral information 5.2\tParticle size and particle size distribution <\/td>\n<\/tr>\n | ||||||
| 20<\/td>\n | 5.3\tAggregation\/agglomeration state in relevant media <\/td>\n<\/tr>\n | ||||||
| 21<\/td>\n | _Hlk289081596 5.4\tShape <\/td>\n<\/tr>\n | ||||||
| 22<\/td>\n | 5.5\tSurface area \/ mass-specific surface area \/ volume-specific surface area <\/td>\n<\/tr>\n | ||||||
| 23<\/td>\n | 5.6\tComposition <\/td>\n<\/tr>\n | ||||||
| 24<\/td>\n | 5.7\tSurface chemistry 5.8\tSurface charge <\/td>\n<\/tr>\n | ||||||
| 25<\/td>\n | 5.9\tSolubility\/dispersibility <\/td>\n<\/tr>\n | ||||||
| 27<\/td>\n | 6\tExpression of measurement results and uncertainties 6.1\tGeneral 6.2\tQuantifying uncertainty <\/td>\n<\/tr>\n | ||||||
| 28<\/td>\n | 6.3\tApplication of uncertainty to nano-objects 6.4\tImportance of validation <\/td>\n<\/tr>\n | ||||||
| 29<\/td>\n | 7\tReporting <\/td>\n<\/tr>\n | ||||||
| 31<\/td>\n | Annex\u00a0A \n(informative)<\/p>\n Diagram illustrating the use of physico-chemical characterization in toxicological testing <\/td>\n<\/tr>\n | ||||||
| 32<\/td>\n | Annex\u00a0B \n(informative)<\/p>\n Example measurement methods and standards <\/td>\n<\/tr>\n | ||||||
| 38<\/td>\n | Bibliography <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":" Nanotechnologies. Guidance on physico-chemical characterization of engineered nanoscale materials for toxicologic assessment<\/b><\/p>\n |